CHOLINE THIEOPHYLLINATE
- Product Name
- CHOLINE THIEOPHYLLINATE
- CAS No.
- 4499-40-5
- Chemical Name
- CHOLINE THIEOPHYLLINATE
- Synonyms
- Sabidal;Teovent;filoral;choledyl;cholegyl;Zy-15061;teokolin;Bronchodil;Sabidal SR;theoxylline
- CBNumber
- CB1441097
- Molecular Formula
- C12H21N5O3
- Formula Weight
- 283.33
- MOL File
- 4499-40-5.mol
CHOLINE THIEOPHYLLINATE Property
- Melting point:
- 176-178 °C
- storage temp.
- Store at -20°C
- solubility
- PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
Safety
- HS Code
- 2939590000
N-Bromosuccinimide Price
- Product number
- 1484009
- Product name
- Oxtriphylline
- Packaging
- 500mg
- Price
- $250
- Updated
- 2024/03/01
- Product number
- 24006
- Product name
- Oxtriphylline
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 24006
- Product name
- Oxtriphylline
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- 24006
- Product name
- Oxtriphylline
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- O867275
- Product name
- Oxytrimethylline
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
CHOLINE THIEOPHYLLINATE Chemical Properties,Usage,Production
Originator
Sabidal ,S.R. Zyma, UK ,1983
Uses
Bronchodilator.
Uses
Oxytrimethylline is used in the treatment for chronic asthma.
Manufacturing Process
18 parts by weight of theophylline are added to 37.8 parts by weight of aqueous choline bicarbonate (47% assay) and the mixture stirred and heated at 80°C to 90°C until the evolution of carbon dioxide has ceased and complete solution effected. Water is separated from the reaction mixture by distillation under a vacuum sufficient to keep the still temperature between 50°C and 55 C. After about 95 parts by weight of water have been separated, about 80 parts by weight of isopropyl alcohol are added and the mixture subjected to further distillation under a vacuum sufficient to keep the mixture boiling at about 40°C. The distillation removes some of the water as an azeotrope with the isopropyl alcohol. During the removal of the water-isopropyl alcohol azeotrope a crystalline precipitate forms. The mixture is further cooled slowly to 5°C and the crystalline precipitate filtered off. The choline theophyllinate crystals are then washed with isopropyl alcohol and dried under vacuum at about 70°C. A second crop of the product may be obtained from the mother liquor by further reduction in volume and cooling. A yield of 90.5% of theory of choline theophyllinate is obtained completely free of inorganic salts.
brand name
Choledyl(Parke-Davis).
Therapeutic Function
Smooth muscle relaxant
CHOLINE THIEOPHYLLINATE Preparation Products And Raw materials
Raw materials
Preparation Products
CHOLINE THIEOPHYLLINATE Suppliers
View Lastest Price from CHOLINE THIEOPHYLLINATE manufacturers
- Product
- CHOLINE THIEOPHYLLINATE 4499-40-5
- Price
- US $8.00/g
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-11-26
- Product
- CHOLINE THIEOPHYLLINATE 4499-40-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-05-28
- Product
- Choline theophyllinate 4499-40-5
- Price
- US $0.01-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50 tons
- Release date
- 2020-04-24